Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab.

Tom Button; Dan Altmann; Dan Tozer; Catherine Dalton; Kelvin Hunter; Alastair Compston; Alasdair Coles; David Miller; (2012) Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab. Multiple sclerosis (Houndmills, Basingstoke, England), 19 (2). pp. 241-244. ISSN 1352-4585 DOI: 10.1177/1352458512444915
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The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density. Mean magnetization transfer ratio fell in 18 untreated patients with multiple sclerosis both in normal appearing grey (-0.25 pu/year, p < 0.001) and white matter (-0.12 pu/year, p = 0.004). Conversely, mean magnetization transfer ratio was stable in 20 alemtuzumab-treated patients (grey matter: -0.01 pu/year, p = 0.87; white matter: -0.02 pu/year, p = 0.51). The gradient difference in grey matter was 0.25 pu/year (p < 0.001) after age-adjustment. These data suggest that in multiple sclerosis alemtuzumab protects against tissue damage in normal-appearing grey matter, perhaps by preventing new lesion formation.

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