The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition.

Francesca L Crowe; Timothy J Key; Naomi E Allen; Paul N Appleby; Andrew Roddam; Kim Overvad; Henning Grønbaek; Anne Tjønneland; Jutte Halkjaer; Laure Dossus; +34 more... Heiner Boeing; Janine Kröger; Antonia Trichopoulou; Vardis Dilis; Dimitrios Trichopoulos; Marie-Christine Boutron-Ruault; Blandine De Lauzon; Françoise Clavel-Chapelon; Domenico Palli; Franco Berrino; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; H Bas Bueno-de-Mesquita; Alina Vrieling; Carla H van Gils; Petra HM Peeters; Inger T Gram; Guri Skeie; Eiliv Lund; Laudina Rodríguez; Paula Jakszyn; Esther Molina-Montes; María J Tormo; Aurelio Barricarte; Nerea Larrañaga; Kay-Tee Khaw; Sheila Bingham; Sabina Rinaldi; Nadia Slimani; Teresa Norat; Valentina Gallo; Elio Riboli; Rudolf Kaaks; (2009) The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer epidemiology, biomarkers & prevention, 18 (5). pp. 1333-1340. ISSN 1055-9965 DOI: 10.1158/1055-9965.EPI-08-0781
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Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend <0.001 for all) and a decrease in IGFBP-2 of 3.5%, 3.5%, and 5.4% (P for trend <0.001 for all), respectively. There were no significant associations between the intake of protein or calcium from nondairy sources and IGF-I. The results from this large cross-sectional analysis show that either the intake of dairy protein or calcium is an important dietary determinant of IGF-I and IGFBP-2 concentrations; however, we suggest that it is more likely to be protein from dairy products.

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