Glycophorins, Blood Groups, and Protection from Severe Malaria.

Samuel C Wassmer ORCID logo; Jane MCarlton; (2015) Glycophorins, Blood Groups, and Protection from Severe Malaria. Trends in parasitology, 32 (1). pp. 5-7. ISSN 1471-4922 DOI: 10.1016/j.pt.2015.11.006
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In Malaŵi, Malungo alibe odi is a saying that translates as: 'Malaria does not ask permission before coming in'. The recent finding of a new severe malaria resistance locus next to a cluster of glycophorin genes involved in Plasmodium falciparum erythrocyte invasion seems to suggest otherwise: that evolutionary pressure is enabling erythrocytes to lock the door to keep malaria out.


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