Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.
Emmanuel C Patin;
Sam Willcocks 
;
Selinda Orr;
Theresa H Ward ;
Roland Lang;
Ulrich E Schaible;
(2016)
Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.
Innate immunity, 22 (3).
pp. 181-185.
ISSN 1753-4259
DOI: 10.1177/1753425916636671
;
Selinda Orr;
Theresa H Ward ;
Roland Lang;
Ulrich E Schaible;
(2016)
Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.
Innate immunity, 22 (3).
pp. 181-185.
ISSN 1753-4259
DOI: 10.1177/1753425916636671
The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
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