Genomic epidemiology of a dengue virus epidemic in urban Singapore.

Mark J Schreiber; Edward C Holmes; Swee Hoe Ong; Harold SH Soh; Wei Liu; Lukas Tanner; Pauline PK Aw; Hwee Cheng Tan; Lee Ching Ng; Yee Sin Leo; +5 more... Jenny GH Low; Adrian Ong; Eng Eong Ooi; Subhash G Vasudevan; Martin L Hibberd; (2009) Genomic epidemiology of a dengue virus epidemic in urban Singapore. Journal of virology, 83 (9). pp. 4163-4173. ISSN 0022-538X DOI: 10.1128/JVI.02445-08
Copy

Dengue is one of the most important emerging diseases of humans, with no preventative vaccines or antiviral cures available at present. Although one-third of the world's population live at risk of infection, little is known about the pattern and dynamics of dengue virus (DENV) within outbreak situations. By exploiting genomic data from an intensively studied major outbreak, we are able to describe the molecular epidemiology of DENV at a uniquely fine-scaled temporal and spatial resolution. Two DENV serotypes (DENV-1 and DENV-3), and multiple component genotypes, spread concurrently and with similar epidemiological and evolutionary profiles during the initial outbreak phase of a major dengue epidemic that took place in Singapore during 2005. Although DENV-1 and DENV-3 differed in viremia and clinical outcome, there was no evidence for adaptive evolution before, during, or after the outbreak, indicating that ecological or immunological rather than virological factors were the key determinants of epidemic dynamics.

Full text not available from this repository.

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads