EC-BLAST: a tool to automatically search and compare enzyme reactions.
Syed Asad Rahman;
Sergio Martinez Cuesta;
Nicholas Furnham 
;
Gemma L Holliday;
Janet M Thornton;
(2014)
EC-BLAST: a tool to automatically search and compare enzyme reactions.
Nature methods, 11 (2).
pp. 171-174.
ISSN 1548-7091
DOI: 10.1038/nmeth.2803
;
Gemma L Holliday;
Janet M Thornton;
(2014)
EC-BLAST: a tool to automatically search and compare enzyme reactions.
Nature methods, 11 (2).
pp. 171-174.
ISSN 1548-7091
DOI: 10.1038/nmeth.2803
We present EC-BLAST (http://www.ebi.ac.uk/thornton-srv/software/rbl/), an algorithm and Web tool for quantitative similarity searches between enzyme reactions at three levels: bond change, reaction center and reaction structure similarity. It uses bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping across each reaction. EC-BLAST has the potential to improve enzyme classification, identify previously uncharacterized or new biochemical transformations, improve the assignment of enzyme function to sequences, and assist in enzyme engineering.
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