Transformations of manool. tri- and tetracyclic norditerpenoids with in vitro activity against Plasmodium falciparum.
Albert WW van Wyk;
Kevin A Lobb;
Mino R Caira;
Heinrich C Hoppe;
Michael T Davies-Coleman;
(2007)
Transformations of manool. tri- and tetracyclic norditerpenoids with in vitro activity against Plasmodium falciparum.
Journal of natural products, 70 (8).
pp. 1253-1258.
ISSN 0163-3864
DOI: 10.1021/np0701071
The known 17-norisopimar-15-ene-8beta,13beta-diol (5) and five new semisynthetic norditerpenoids, ethyl 17-norabiet-13(15)-E-en-8beta-ol-16-oate (6), ethyl 17-norabiet-13(15)-Z-en-8beta-ol-16-oate (7), 17-norpimaran-13alpha-ethoxy-8,16-olactone (8), 17-norisopimarane-8beta,15-diol (9), and 17-norarabiet-13(15)-ene-8beta,16-diol (10), were prepared from manool (11). Standard spectroscopic data including X-ray crystal analysis were used to determine the structures of 5-10. All five compounds exhibited in vitro antiplasmodial activity against the malarial parasite Plasmodium falciparum at varying microg mL(-1) concentrations.
| Item Type | Article |
|---|---|
| Keywords | Animals, Antimalarials, chemical synthesis, chemistry, pharmacology, Crystallography, X-Ray, Diterpenes, chemical synthesis, chemistry, pharmacology, Erythrocytes, metabolism, Humans, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plasmodium falciparum, drug effects |
| ISI | 248978800007 |