Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis.
Nikolaus Michael;
Andreas Erfurth;
Peter Lüdemann;
Gerhard Schuierer;
Harald E Möller;
(2005)
Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis.
Psychiatry research, 139 (3).
pp. 269-273.
ISSN 0165-1781
DOI: 10.1016/j.pscychresns.2005.01.003
A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy. Metabolic abnormalities included decreased N-acetylaspartate and elevated choline and myo-inositol in a lesion visible on magnetic resonance imaging and in normal-appearing white matter. Lactate appeared increased within the lesion. Metabolic impairment was persistent after intrathecal interferon-alpha treatment. Spectroscopy pointing to ongoing inflammation, gliosis, and possible membrane turnover was more sensitive than imaging in detecting widespread pathology within the white matter.
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