Steric constraints dependent on nucleobase pair orientation vary in different DNA polymerase active sites.
Frank Streckenbach;
Gopinath Rangam;
Heiko M Möller;
Andreas Marx;
(2009)
Steric constraints dependent on nucleobase pair orientation vary in different DNA polymerase active sites.
Chembiochem : a European journal of chemical biology, 10 (10).
pp. 1630-1633.
ISSN 1439-7633
DOI: 10.1002/cbic.200900123
Finding the right fit: Herein, we report on the development of novel steric probes and present initial insights into their interplay with DNA polymerases. Our findings provide experimental evidence for varied enzyme-substrate interactions that might account for the varied selectivity previously observed.
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