Multicentre patch testing with a resol resin based on phenol and formaldehyde.

Marléne Isaksson; Annica Inerot; Carola Lidén; Mihaly Matura; Berndt Stenberg; Halvor Möller; Magnus Bruze; (2011) Multicentre patch testing with a resol resin based on phenol and formaldehyde. Contact dermatitis, 65 (1). pp. 34-37. ISSN 1600-0536 DOI: 10.1111/j.1600-0536.2011.01921.x
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BACKGROUND: Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin (PTBP-FR) included in most baseline patch test series. OBJECTIVES: To investigate the rate of contact allergy to PFR-2 (a mixture of monomers and dimers from a resol resin based on phenol and formaldehyde) in a Swedish population, and to investigate associated simultaneous allergic reactions. METHODS: Five centres representing the Swedish Contact Dermatitis Research Group included PFR-2 in their patch test baseline series for a period of 1.5 years. RESULTS: Of 2504 patients tested, 27 (1.1%) reacted to PFR-2. Of those 27 individuals, 2 had a positive reaction to formaldehyde and 2 to PTBP-FR. Simultaneous allergic reactions were noted to colophonium in 6, to Myroxylon pereirae in 14, and to fragrance mix I in 15. CONCLUSIONS: The contact allergy frequency in the tested population (1.1%) merits its inclusion in the Swedish baseline series and possibly also in other baseline series. Simultaneous allergic reactions were noted to colophonium, M. pereirae, and fragrance mix I.

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