Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

MaríaSoler Artigas; Daan WLoth; Louise VWain; Sina AGharib; Ma'enObeidat; WenboTang; GuangjuZhai; Jing HuaZhao; Albert VernonSmith; Jennifer EHuffman; +161 more... EvaAlbrecht; Catherine MJackson; David MEvans; GemmaCadby; MyriamFornage; AniManichaikul; Lorna MLopez; TobyJohnson; Melinda CAldrich; ThorAspelund; InêsBarroso; HarryCampbell; Patricia ACassano; David JCouper; GudnyEiriksdottir; NoraFranceschini; MelissaGarcia; ChristianGieger; Gauti KjartanGislason; IvicaGrkovic; Christopher JHammond; Dana BHancock; Tamara BHarris; AdaikalavanRamasamy; Susan RHeckbert; MarkkuHeliövaara; GeorgHomuth; Pirro GHysi; Alan LJames; StipanJankovic; Bonnie RJoubert; StefanKarrasch; NormanKlopp; BeateKoch; Stephen BKritchevsky; Lenore JLauner; YongmeiLiu; Laura RLoehr; KurtLohman; Ruth JFLoos; ThomasLumley; Khalid AAl Balushi; Wei QAng; R GrahamBarr; JohnBeilby; John DBlakey; MladenBoban; VesnaBoraska; JonasBrisman; John RBritton; Guy GBrusselle; CyrusCooper; IvanCurjuric; SantoshDahgam; Ian JDeary; ShahEbrahim; MarkEijgelsheim; ClydeFrancks; DaryaGaysina; RaquelGranell; XiangjunGu; John LHankinson; RebeccaHardy; Sarah EHarris; JohnHenderson; AmandaHenry; Aroon DHingorani; AlbertHofman; Patrick GHolt; JennieHui; Michael LHunter; MedeaImboden; Karen AJameson; Shona MKerr; IvanaKolcic; FlorianKronenberg; Jason ZLiu; JonathanMarchini; TriciaMcKeever; Andrew DMorris; Anna-CarinOlin; David JPorteous; Dirkje SPostma; Stephen SRich; Susan MRing; FernandoRivadeneira; ThierryRochat; Avan AihieSayer; IanSayers; Peter DSly; George DaveySmith; AkshaySood; John MStarr; André GUitterlinden; Judith MVonk; S GoyaWannamethee; Peter HWhincup; CiscaWijmenga; O DaleWilliams; AndrewWong; MassimoMangino; Kristin DMarciante; Wendy LMcArdle; BerndMeibohm; Alanna CMorrison; Kari ENorth; ErnstOmenaas; Lyle JPalmer; Kirsi HPietiläinen; IsabellePin; OzrenPola Sbreve Ek; AnneliPouta; Bruce MPsaty; Anna-LiisaHartikainen; TainaRantanen; SamuliRipatti; Jerome IRotter; IgorRudan; Alicja RRudnicka; HolgerSchulz; So-YounShin; Tim DSpector; IdaSurakka; VeroniqueVitart; HenryVölzke; Nicholas JWareham; Nicole MWarrington; H-ErichWichmann; Sarah HWild; Jemma BWilk; MatthiasWjst; Alan FWright; LinaZgaga; TatijanaZemunik; Craig EPennell; FredrikNyberg; DianaKuh; John WHolloway; H MarikeBoezen; Debbie ALawlor; Richard WMorris; NicoleProbst-Hensch; International Lung Cancer Consortium; GIANT consortium; JaakkoKaprio; James FWilson; CarolineHayward; MikaKähönen; JoachimHeinrich; Arthur WMusk; Deborah LJarvis; SvenGläser; Marjo-RiittaJärvelin; Bruno HCh Stricker; PaulElliott; George TO'Connor; David PStrachan; Stephanie JLondon; Ian PHall; VilmundurGudnason; Martin DTobin; (2011) Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature genetics, 43 (11). pp. 1082-1090. ISSN 1061-4036 DOI: 10.1038/ng.941
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Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
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ISI 296584000011

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