The molecular basis of the antigenic cross-reactivity between measles and cowpea mosaic viruses.

Wieslawa Olszewska; Michael W Steward; (2003) The molecular basis of the antigenic cross-reactivity between measles and cowpea mosaic viruses. Virology, 310 (1). pp. 183-189. ISSN 0042-6822 DOI: 10.1016/s0042-6822(03)00118-1
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Two nonrelated viruses, cowpea mosaic virus (wtCPMV) and measles virus (MV), were found to induce cross-reactive antibodies. The nature of this cross-reactivity was studied and results are presented here demonstrating that antiserum raised against wtCPMV reacted with peptide from the fusion (F) protein of MV. Furthermore, the F protein of MV was shown to share an identical conformational B cell epitope with the small subunit of CPMV coat protein. Passive transfer of anti-wtCPMV antibodies into BALB/c mice conferred partial protection against measles virus induced encephalitis. The results are discussed in the context of cross-protection.

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