Interleukin-13 in Iranian patients with visceral leishmaniasis: relationship to other Th2 and Th1 cytokines.
The role of interleukin (IL)-13, a Th2 cytokine sharing many of the features of IL-4, has not previously been examined in patients with visceral leishmaniasis (VL). We examined sera from Iranian patients with VL caused by Leishmania infantum. Serum IL-13 was detected in 50% (22/44) of patients with active primary disease. In comparison, IL-10 was detected in 79.5% (35/44), interferon gamma (IFN gamma) in 38.5% (17/44), and IL-4 in only 5% (2/44) of these patients. With few exceptions all 3 cytokines were undetectable after clinical recovery following antimony therapy. Five of 7 patients (71%) who failed antimony therapy and had relapsing disease had similar levels of IL-10 to patients with active primary disease. However, with only 1 exception, IL-13, IFN gamma and IL-4 were not detected in such patients. These data suggest that relapsing disease may result from defective cellular immunity, unrelated to immunosuppression mediated by IL-10.
| Item Type | Article |
|---|---|
| Keywords | visceral leishmaniasis, Leishmania infantum, cytokines, interleukin-4, interleukin-10, interleukin-13, interferon, gamma, Iran, Cell-associated cytokines, interferon-gamma, kala-azar, t-, cells, donovani, inflammation, responses, infection, profiles, il-13, Animal, Antibodies, Protozoan, blood, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Human, Infant, Interferon Type II, blood, Interleukin-10, blood, Interleukin-13, blood, Iran, Leishmania donovani, immunology, Leishmaniasis, Visceral, blood, Male, Support, Non-U.S. Gov't |
| ISI | 167561600025 |