HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
Michèl R Klein;
Abdulrahman S Hammond;
Steve M Smith;
Assan Jaye;
Pauline T Lukey;
Keith PWJ McAdam;
(2002)
HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
Infection and immunity, 70 (2).
pp. 981-984.
ISSN 0019-9567
DOI: 10.1128/IAI.70.2.981-984.2002
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.
| Item Type | Article |
|---|---|
| Keywords | Class-i molecules, cd8(+) t-cells, interferon-gamma, peptides, binding, Antigens, Bacterial, immunology, CD8-Positive T-Lymphocytes, immunology, Cytotoxicity Tests, Immunologic, Epitope Mapping, Epitopes, T-Lymphocyte, immunology, HLA-B35 Antigen, immunology, Human, Interferon Type II, analysis, Leukocytes, Mononuclear, immunology, Macrophages, immunology, microbiology, Mycobacterium tuberculosis, immunology, Peptides, immunology, Support, Non-U.S. Gov't, Tumor Necrosis Factor, analysis |
| ISI | 173555800069 |