Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia.
J Vekemans;
C Lienhardt;
JS Sillah;
JG Wheeler;
GP Lahai;
MT Doherty;
T Corrah;
P Andersen;
KP McAdam;
A Marchant;
(2001)
Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia.
Infection and immunity, 69 (10).
pp. 6554-6557.
ISSN 0019-9567
DOI: 10.1128/IAI.69.10.6554-6557.2001
The Mycobacterium tuberculosis antigen ESAT-6 has been proposed for tuberculosis immunodiagnosis. In The Gambia, 30% of community controls produced gamma interferon (IFN-gamma) in response to ESAT-6. Increased proportions of responders and intensities of responses were found in household contacts. Responses that were initially low in tuberculosis patients increased after treatment. An ESAT-6 IFN-gamma assay will be of limited use in the diagnosis of tuberculosis in countries where tuberculosis is endemic. Its role in contact tracing should be evaluated further.
| Item Type | Article |
|---|---|
| Keywords | T-cell responses, mycobacterium-tuberculosis, mortality, Adolescence, Adult, Antigens, Bacterial, immunology, pharmacology, Biological Markers, Cells, Cultured, Community-Acquired Infections, immunology, Endemic Diseases, Female, Gambia, epidemiology, Human, Interferon Type II, blood, Leukocytes, Mononuclear, cytology, drug effects, immunology, Male, Middle Age, Mycobacterium tuberculosis, immunology, Prospective Studies, Support, Non-U.S. Gov't, Tuberculin Test, Tuberculosis, Pulmonary, blood, epidemiology, immunology, transmission |
| ISI | 171121100076 |