Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.

B-S Choi; I Clara Martinez-Falero; C Corset; M Munder; M Modolell; I Müller; P Kropf; (2009) Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. Journal of leukocyte biology, 85 (2). pp. 268-277. ISSN 0741-5400 DOI: 10.1189/jlb.0508310
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The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MPhi) effector functions: We show that whereas L-arginine is required unconditionally for T cell activation, MPhi can up-regulate activation markers and produce cytokines and chemokines in the absence of L-arginine. Furthermore, we show that L-arginine deprivation does not affect the capacity of activated MPhi to up-regulate L-arginine-metabolizing enzymes such as inducible NO synthase and arginase 1. Thus, our results show that to exert their effector functions, T cells and MPhi have different requirements for L-arginine.


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