Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.
The metabolism of the amino acid L-arginine is emerging as a crucial mechanism for the regulation of immune responses. Here, we characterized the impact of L-arginine deprivation on T cell and macrophage (MPhi) effector functions: We show that whereas L-arginine is required unconditionally for T cell activation, MPhi can up-regulate activation markers and produce cytokines and chemokines in the absence of L-arginine. Furthermore, we show that L-arginine deprivation does not affect the capacity of activated MPhi to up-regulate L-arginine-metabolizing enzymes such as inducible NO synthase and arginase 1. Thus, our results show that to exert their effector functions, T cells and MPhi have different requirements for L-arginine.
Item Type | Article |
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ISI | 262891700009 |
Explore Further
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642643 (OA Location)
- 10.1189/jlb.0508310 (DOI)
- 19008294 (PubMed)