Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity.
Simona Stäger;
James Alexander;
K Christine Carter;
Frank Brombacher;
Paul M Kaye;
(2003)
Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity.
Infection and immunity, 71 (8).
pp. 4804-4807.
ISSN 0019-9567
DOI: 10.1128/IAI.71.8.4804-4807.2003
The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.
| Item Type | Article |
|---|---|
| ISI | 184392700068 |