Discrimination of single-copy IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates by high-resolution minisatellite-based typing.
Ann SG Lee;
Lynn LH Tang;
Irene HK Lim;
Richard Bellamy;
Sin-Yew Wong;
(2002)
Discrimination of single-copy IS6110 DNA fingerprints of Mycobacterium tuberculosis isolates by high-resolution minisatellite-based typing.
Journal of clinical microbiology, 40 (2).
pp. 657-659.
ISSN 0095-1137
DOI: 10.1128/JCM.40.2.657-659.2002
Seven isoniazid-resistant isolates with mutations in the NADH dehydrogenase (ndh) gene were molecularly typed by IS6110-based restriction fragment length polymorphism analysis. All seven isolates with the R268H mutation had identical 1.4-kb IS6110 fingerprints. High-resolution minisatellite-based typing discriminated five of these isolates; two isolates were identical.
| Item Type | Article |
|---|---|
| Keywords | Bacterial Typing Techniques, DNA Fingerprinting, methods, DNA Transposable Elements, Human, Minisatellite Repeats, genetics, Mycobacterium tuberculosis, classification, genetics, isolation & purification, Polymorphism, Restriction Fragment Length, Support, Non-U.S. Gov't, Tuberculosis, Pulmonary, microbiology |
| ISI | 173731900054 |