Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.
Koya Ariyoshi;
Neil Berry;
Fatim Cham;
Shabbar Jaffar;
Maarten Schim van der Loeff;
Ousman Jobe;
Pa Tamba N'Gom;
Olav Larsen;
Sören Andersson;
Peter Aaby;
+1 more...
Hilton Whittle;
(2003)
Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.
The Journal of infectious diseases, 188 (11).
pp. 1648-1651.
ISSN 0022-1899
DOI: 10.1086/379780
Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.
| Item Type | Article |
|---|---|
| ISI | 187493200005 |