Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice.
MV Khoretonenko;
MF Vorovitch;
LG Zakharova;
GV Pashvykina;
NV Ovsyannikova;
JR Stephenson;
AV Timofeev;
AD Altstein;
AM Shneider;
(2003)
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice.
Immunology letters, 90 (2-3).
pp. 161-163.
ISSN 0165-2478
DOI: 10.1016/j.imlet.2003.09.002
A vaccinia virus recombinant containing the non-structural tick-borne encephalitis virus (TBEV) NS1 gene was developed. The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV.
| Item Type | Article |
|---|---|
| Keywords | tick-borne encephalitis virus, vaccinia virus, NS1 protein, protective activity, murine model, lymphocytes |
| ISI | 188127100015 |