Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002.

J Anthony G Scott

; Salim Mwarumba; Caroline Ngetsa; Salome Njenga; Brett S Lowe; Mary PE Slack; James A Berkley; Isaiah Mwangi; Kathryn Maitland; Mike English; +1 more... Kevin Marsh; (2005) Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002. Antimicrobial agents and chemotherapy, 49 (7). pp. 3021-3024. ISSN 0066-4804 DOI: 10.1128/AAC.49.7.3021-3024.2005

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Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.