Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Sara Lindström;
Celine M Vachon;
Jingmei Li;
Jajini Varghese;
Deborah Thompson;
Ruth Warren;
Judith Brown;
Jean Leyland;
Tina Audley;
Nicholas J Wareham;
+25 more...
Ruth JF Loos;
Andrew D Paterson;
Johanna Rommens;
Darryl Waggott;
Lisa J Martin;
Christopher G Scott;
V Shane Pankratz;
Susan E Hankinson;
Aditi Hazra;
David J Hunter;
John L Hopper;
Melissa C Southey;
Stephen J Chanock;
Isabel dos Santos Silva;
JianJun Liu;
Louise Eriksson;
Fergus J Couch;
Jennifer Stone;
Carmel Apicella;
Kamila Czene;
Peter Kraft;
Per Hall;
Douglas F Easton;
Norman F Boyd;
Rulla M Tamimi;
(2011)
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Nature genetics, 43 (3).
pp. 185-187.
ISSN 1061-4036
DOI: 10.1038/ng.760
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
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