Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.

SaraLindström; Celine MVachon; JingmeiLi; JajiniVarghese; DeborahThompson; RuthWarren; JudithBrown; JeanLeyland; TinaAudley; Nicholas JWareham; +25 more... Ruth JFLoos; Andrew DPaterson; JohannaRommens; DarrylWaggott; Lisa JMartin; Christopher GScott; V ShanePankratz; Susan EHankinson; AditiHazra; David JHunter; John LHopper; Melissa CSouthey; Stephen JChanock; Isabel dos SantosSilva; JianJunLiu; LouiseEriksson; Fergus JCouch; JenniferStone; CarmelApicella; KamilaCzene; PeterKraft; PerHall; Douglas FEaston; Norman FBoyd; Rulla MTamimi; (2011) Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nature genetics, 43 (3). pp. 185-187. ISSN 1061-4036 DOI: 10.1038/ng.760
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High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
Item Type Article
ISI 287693800007

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