Comparison of careHPV and hybrid capture 2 assays for detection of high-risk human Papillomavirus DNA in cervical samples from HIV-1-infected African women.

Jean Ngou; Mahlape P Magooa; Clare Gilham

; Florencia Djigma; Marie-Noelle Didelot; Helen Kelly

; Albert Yonli; Bernard Sawadogo; David A Lewis; Sinead Delany-Moretlwe; +3 more... Philippe Mayaud

; Michel Segondy; HARP Study Group; (2013) Comparison of careHPV and hybrid capture 2 assays for detection of high-risk human Papillomavirus DNA in cervical samples from HIV-1-infected African women. Journal of clinical microbiology, 51 (12). pp. 4240-4242. ISSN 0095-1137 DOI: 10.1128/JCM.02144-13

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The careHPV and HC2 assays were compared for high-risk human papillomavirus (HR-HPV) DNA detection in cervical samples from 149 HIV-1-infected African women. The HR-HPV DNA detection rates were 37.6% and 34.9% for careHPV and HC2, respectively. Agreement between the two tests was 94.6% (95% confidence interval [CI], 89.7% to 97.7%) with a kappa value of 0.88 (95% CI, 0.81 to 0.96), indicating an excellent agreement. careHPV may be considered as suitable as HC2 for cervical cancer screening among HIV-infected African women.