Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.
Nikhil H Gokhale;
K Shirisha;
Subhash B Padhye;
Simon L Croft 
;
Howard D Kendrick;
Vickie Mckee;
(2006)
Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.
Bioorganic & medicinal chemistry letters, 16 (2).
pp. 430-432.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.09.061
;
Howard D Kendrick;
Vickie Mckee;
(2006)
Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.
Bioorganic & medicinal chemistry letters, 16 (2).
pp. 430-432.
ISSN 0960-894X
DOI: 10.1016/j.bmcl.2005.09.061
The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target.
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