Clinicopathological review of ocular surface squamous neoplasia in Malawi.

T Tiong; S Borooah; J Msosa; W Dean; C Smith; E Kambewa; C Kiire; M Zondervan ORCID logo; P Aspinall; B Dhillon; (2013) Clinicopathological review of ocular surface squamous neoplasia in Malawi. The British journal of ophthalmology, 97 (8). pp. 961-964. ISSN 0007-1161 DOI: 10.1136/bjophthalmol-2012-302533
Copy

BACKGROUND: Ocular surface squamous neoplasia (OSSN) is the most common cause of malignancy of the conjunctiva. Variable clinical presentation means that invasive malignant OSSN is often difficult to discriminate from other similarly presenting differential diagnoses which can be managed more conservatively. AIMS: Identification of clinical factors associated with a histopathological diagnosis of conjunctival squamous cell carcinoma (SCC). METHODS: Prospective consecutive case series of suspected OSSN cases presenting at two hospitals in Central Malawi over a 1 year period. A pro forma was completed assessing preidentified clinical variables. Suspected lesions underwent excisional biopsy followed by histopathological investigation. RESULTS: Fifty-eight patients were recruited. Mean age was 35.8 (range 22-62). 51 cases of histopathologically confirmed OSSN were found. 30 (50%) patients were confirmed HIV seropositive which rose to 86.67% in invasive SCC. Larger size of tumour (p=0.008), male gender (p=0.025) and HIV seropositivity (p=0.010) were associated with invasive SCC pathology. CONCLUSIONS: A clinicopathological study of OSSN has not previously been performed in Malawi. The association of HIV with SCC corresponds to previous reports from sub-Saharan Africa. A new finding in our study is a relationship between larger tumour size and invasive lesions confirmed by histopathology. When integrated into a clinical decision-making model, tumour area provides a simple clinical measure for ophthalmic practitioners to use in order to differentiate higher risk OSSN from more benign pathology. The higher risk lesions can subsequently be treated with greater surgical care and undergo closer follow-up.

Full text not available from this repository.

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads