Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.
Rosalind Polley;
Simona Stager;
Sara Prickett;
Asher Maroof;
Soombul Zubairi;
Deborah F Smith;
Paul M Kaye;
(2006)
Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.
Infection and immunity, 74 (1).
pp. 773-776.
ISSN 0019-9567
DOI: 10.1128/IAI.74.1.773-776.2006
CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
| Item Type | Article |
|---|---|
| Keywords | Animals, Antigens, Protozoan, immunology, CD8-Positive T-Lymphocytes, immunology, Immunotherapy, Adoptive, Leishmania donovani, genetics, immunology, Leishmaniasis, Visceral, immunology, therapy, Mice, Mice, Transgenic, Ovalbumin, biosynthesis, genetics, Research Support, Non-U.S. Gov't |
| ISI | 234276400086 |