Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.

RosalindPolley; SimonaStager; SaraPrickett; AsherMaroof; SoombulZubairi; Deborah FSmith; Paul MKaye; (2006) Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen. Infection and immunity, 74 (1). pp. 773-776. ISSN 0019-9567 DOI: 10.1128/IAI.74.1.773-776.2006
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CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
Item Type Article
Keywords Animals, Antigens, Protozoan, immunology, CD8-Positive T-Lymphocytes, immunology, Immunotherapy, Adoptive, Leishmania donovani, genetics, immunology, Leishmaniasis, Visceral, immunology, therapy, Mice, Mice, Transgenic, Ovalbumin, biosynthesis, genetics, Research Support, Non-U.S. Gov't
ISI 234276400086

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