Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa.

G Luoni; F Verra; B Arcà; BS Sirima; M Troye-Blomberg; M Coluzzi; D Kwiatkowski; D Modiano; (2001) Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa. Genes and immunity, 2 (7). pp. 411-414. ISSN 1466-4879 DOI: 10.1038/sj.gene.6363797
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The Fulani are less clinically susceptible and more immunologically responsive to malaria than neighbouring ethnic groups. Here we report that anti-malarial antibody levels show a wide distribution amongst the Fulani themselves, raising the possibility that quantitative analysis within the Fulani may be an efficient way of screening for important genetic factors. The Th2 cytokine interleukin-4 is an obvious candidate: in Fulani, the IL4-524 T allele is at high frequency and is associated with elevated antibody levels against malaria antigens. These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting.

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