Iron and microbial infection.
Ulrich ESchaible;
Stefan HEKaufmann;
(2004)
Iron and microbial infection.
Nature reviews Microbiology, 2 (12).
pp. 946-953.
ISSN 1740-1526
DOI: 10.1038/nrmicro1046
The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. It is also a pivotal component of the innate immune response through its role in the generation of toxic oxygen and nitrogen intermediates. During evolution, the shared requirement of micro- and macroorganisms for this important nutrient has shaped the pathogen-host relationship. Here, we discuss how pathogens compete with the host for iron, and also how the host uses iron to counteract this threat.
Item Type | Article |
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ISI | 225492700012 |
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