Miltefosine: issues to be addressed in the future.

JBerman; ADMBryceson; S Croft ORCID logo; JEngel; WGutteridge; JKarbwang; HSindermann; JSoto; SSundar; JAUrbina; (2006) Miltefosine: issues to be addressed in the future. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100 Su. S41-S44. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2006.02.009
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Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions.
Item Type Article
Keywords visceral leishmaniasis, cutaneous leishmaniasis, mucosal leishmaniasis, miltefosine, resistance, toxicity, GLYCOPROTEIN-LIKE TRANSPORTER, P-GLYCOPROTEIN, MULTIDRUG-RESISTANCE, HEXADECYLPHOSPHOCHOLINE MILTEFOSINE, REVERSAL AGENTS, IN-VITRO, LEISHMANIA, DRUG, SESQUITERPENES
ISI 242138800008

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