Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.
Ana Cehovin;
Jacqueline M Cliff 
;
Philip C Hill;
Roger H Brookes;
Hazel M Dockrell ;
(2007)
Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.
Clinical and vaccine immunology, 14 (6).
pp. 796-798.
ISSN 1556-6811
DOI: 10.1128/CVI.00093-07
;
Philip C Hill;
Roger H Brookes;
Hazel M Dockrell ;
(2007)
Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.
Clinical and vaccine immunology, 14 (6).
pp. 796-798.
ISSN 1556-6811
DOI: 10.1128/CVI.00093-07
To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.
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